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عمومی::
پپتید ناتریورتیک مغز
The PARADIGM-HF trial was a randomized, double-blind, active treatment-controlled, clinical trial performed from performed from December 8, 2009, to March 31, 2014, that enrolled patients 18 years or older who had heart failure and left ventricular ejection fraction (LVEF) of 40% or less, New York Heart Association (NYHA) class II to IV disease, and a serum brain-type natriuretic peptide (BNP) level greater than 150 pg/mL, an N-terminal pro-brain-type natriuretic peptide (NT-proBNP) level greater than 600 pg/mL (to convert BNP and NT-proBNP levels to nanograms per liter, multiply by 1), or a heart failure-associated hospitalization within 12 months before enrollment.
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